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KMID : 0376319930050010151
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Dental Journal of CNU
1993 Volume.5 No. 1 p.151 ~ p.163
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THE EFFECT OF BOVINE BONE MORPHOGENETIC PROTEIN ON REPAIR OF THE BONE DEFECT AROUND IMPLANT IN DOG
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Jung Moo-Gang
Chung Sung-Su
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Abstract
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The porpose of this study was to evaluate the effect of the bone matrix gelatin and bone morphogenetic protein on amount and shape of regenerating new bone adjacent to implant.
Implants were placed in canine mandible at 2 months after teeth extraction. Artificial bone defects 3㎜ in diameter and 4㎜ in depth were performed at the mesial and distal side of implant. The mesial defect was filled with the bone matrix gelatin, and the distal defect with the bone morphogenetic protein.
The animals were sacrified at 1, 3, 5, and 10 weeks after implantation for light microscopic evaluation.
Although there were differences in degree between bone matrix gelatin and bone morphogenetic protein, bone regenerating activities were observed in all defect sites.
Bone morphogenetic protein had a more excellent bone forming activity than bone matrix gelatin in the repair of the bone defects.
Compared with bone morphogenetic protein group, downward growth of fibrous connective tissue was observed in bone matrix gelation group, and bone level of bone matrix gelatin group was lower than that of bone morphogenetic protein group.
Above results suggest that success rate of implant was increased when bone morphogenetic protein was implanted to the bony defects by immediate implantation after tooth extraction or in space between implant fixture and bone tissue, and also bone morphogenetic protein could be applied in reconstruction of bone defects caused by diseases or trauma.
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